中科院纳米生物效应与安全性重点实验室
纳米技术论坛 (NS Forum No.267)
第267期学术报告会通知

演讲人: Jinyao Liu, Ph.D.
             Koch Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 USA 
题   目: Development of innovative engineering methodologies for precisely defined polymeric therapeutics
时   间: 2016年5月26日 (星期四), 上午10:00 
地   点: 国家纳米科学中心，南楼四层会议室
主持人: 陈春英 研究员 

摘    要： 
Development of innovative engineering methodologies that allow for preparation of precisely defined polymeric therapeutics has significant fundamental interest and enormous potential for medical applications. In my postdoc research, various versatile approaches have been successfully developed for preparation of well-defined polymeric therapeutics including drug loaded nanoparticles, polymer-protein/peptide conjugates, and gastric-residence devices. In terms of drug loaded nanoparticles, a general method has been developed to prepare drug loaded nanoparticles via ring-opening polymerization of prodrugs, in which drug loading and release can be controlled easily. For protein/peptide delivery, a modular method has been established to engineer protein/peptide–polymer conjugates in a well-controlled manner of site–specific, stoichiometric, and high yield, which combines recombinant expression, enzyme–mediated ligation and click chemistry. In respect to prolonged gastric retention with improved safety profile, a triggerable gastric device has been constructed by using double-network tough hydrogel that helped to achieve long-term drug release of 8 days in a large animal model with the aim to solve poor medication adherence. The application of these polymeric therapeutics will be further discussed by giving examples of treating solid tumour, type-2 diabetes and malaria.