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[7.12]NS Forum No. 271-Implication and Application of Direct Cellular Reprogramming
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| 2016-07-06 | 浏览次数: | 文章来源: | 【大 中 小】 |
中科院纳米生物效应与安全性重点实验室
纳米技术论坛 (NS Forum No.271)
第271期学术报告会通知
演讲人: Prof. Kam W. Leong, Columbia University
题 目: Implication and Application of Direct Cellular Reprogramming
时 间: 2016年7月12日 (星期二), 上午10: 00
地 点: 国家纳米科学中心, 南楼二层会议室
主持人: 赵宇亮 研究员
Abstract: Direct cell reprogramming, where differentiated cells are reprogrammed into another lineage without going through an intermediate stem cell-like stage, produces cells promising for regenerative medicine. It obviates the use of embryos and minimizes the risk of teratoma formation associated with the use of induced pluripotent stem cells. Direct reprogramming can also produce cells for disease modeling and drug screening. I will discuss our recent effort to convert human endothelial progenitors (hEPC) into induced smooth muscle cells (iSMC), hEPC into induced skeletal myocytes (iSkM), and human fibroblasts into induced cardiomyocyte-like cells (iSML). I will describe various approaches of achieving direct cell reprogramming using transcription factor overexpression, microRNA delivery, molecular pathway manipulation, and CRISPR/dCas9-based transactivation either separately or in combination. |
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