中科院纳米生物效应与安全性重点实验室  
纳米技术论坛 (NS Forum No. 333)  
第333期学术报告会通知 

演讲者： 马迪龙（Edmond Ma Dik-Lung）副教授，香港浸会大学
题    目： Modulating Protein-Protein Interaction with Small Molecules
时    间： 2019 年 12月 11日，（星期三）下午14:00
地    点： 国家纳米科学中心，南楼二层会议室
主持人： 王浩  研究员  

报告人简介：
Dr. Ma is currently an associate professor of department of chemistry. His research field mainly focus on (i) organometallic complex synthesis, (ii) PPI modulator discovery, and (iii) computer-aided structural design and screening. He is one of the few experienced Principal Investigators in Hong Kong that possesses the unique combination of the above  fields. And since as an independent principal investigator in 2010, Dr. Ma has published over 290 articles in his research field, such as J. Am. Soc. Chem., Angew. Chem. Int. Ed., Chem. Sci. J. Med. Chem. Chem. Soc. Rev 

摘要：
Protein-protein interactions (PPIs) are of pivotal importance in the regulation of biological systems and are consequently implicated in the development of disease states. Recent work has begun to show that, with the right tools, certain classes of PPI can yield to the efforts of medicinal chemists to develop inhibitors, and the first PPI inhibitors have reached clinical development. As an emerging solution to prevent the diseases caused by PPIs, small molecules functioning as inhibitors to disrupt the original interactions between protein and protein by binding into pockets on the surface of the globular protein. Thus, it would be promising candidates to treart various cancers. In addition, in silico techniques have been utilized to discover natural products that directly target the PPIs, which tremendously reduces the unnecessary  tasks and improves the accuracy of specific targeting.